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Updated: Feb 6, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Recommendations for evaluating and managing idiopathic pulmonary fibrosis
Daniel M Provencher1, Andrew R Jauregui
1Daniel M. Provencher is an assistant professor and clinical coordinator at Midwestern University in Downers Grove, Ill. At the time this article was written, Andrew R. Jauregui was a student in the PA program at Midwestern University. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive and irreversible fibrosis of lung parenchyma that reduces lung function. This rare, incurable disease often is mistaken for an inflammatory condition. IPF typically manifests in older men and is associated with a history of smoking. Disease progression is rapid, with a 5-year survival rate of 20%. Treatment options include lung transplantation and medical therapies to reduce the steady decline in lung function. This article reviews the epidemiology, pathophysiology, presentation, diagnosis, and management of IPF.
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