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Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism
Published on: July 5, 2014
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Atypical structural and functional motor networks in autism
Dorothea L Floris1, Henrietta Howells2
1Department of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone Health, Child Study Center, New York, NY, United States.
Progress in Brain Research
|August 12, 2018
Summary
Individuals with autism spectrum disorder (ASD) exhibit atypical brain hemispheric specialization, particularly in motor functions. This atypical motor lateralization may represent a stable neural marker for ASD subgroups.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Cognitive Neuroscience
Background:
- Cerebral hemispheres exhibit specialized functions, with language and motor control typically lateralized to the left.
- Autism spectrum disorder (ASD) is characterized by social communication and language deficits, alongside motor symptoms.
- Atypical hemispheric specialization is theorized to underlie ASD neuropathology, with preserved right hemisphere function.
Purpose of the Study:
- To review the literature on atypical hemispheric specialization in the motor domain within autism spectrum disorder (ASD).
- To explore motor lateralization as a potential neural phenotype for identifying subgroups within the heterogeneous autism spectrum.
Main Methods:
- Literature review of studies investigating hemispheric specialization in motor functions in individuals with ASD.
- Analysis of structural, functional, and behavioral data related to motor lateralization in ASD.
Main Results:
- Atypical motor lateralization is observed in individuals with ASD.
- This atypical lateralization appears consistent across different measures (structural, functional, behavioral).
Conclusions:
- Atypical motor lateralization is a potential candidate neural phenotype for autism spectrum disorder (ASD).
- This finding may aid in identifying distinct subgroups within the autism spectrum.
- Motor lateralization offers a stable measure for understanding ASD neuropathology.
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