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Immune check-point in cervical cancer.

F De Felice1, C Marchetti2, I Palaia2

  • 1Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.

Critical Reviews in Oncology/Hematology
|August 12, 2018
PubMed
Summary

Locally advanced cervical cancer (CC) remains difficult to treat. This review highlights immune checkpoint inhibitors as a promising therapy to improve treatment response and survival for patients with this challenging cancer.

Keywords:
CTLA-4Cervical cancerImmune check-pointImmunotherapyIpilimumabNivolumabPD-1Pembrolizumab

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Area of Science:

  • Oncology
  • Immunology
  • Gynecologic Oncology

Background:

  • Locally advanced cervical cancer (CC) presents a significant global health challenge with high rates of persistent and recurrent disease despite various treatment modalities.
  • Current treatment strategies often fall short, necessitating the exploration of novel therapeutic approaches.

Purpose of the Study:

  • To review the current landscape of immune checkpoint inhibitors (ICIs) in the management of locally advanced cervical cancer.
  • To present pivotal clinical trials evaluating the efficacy and safety of ICIs in this patient population.

Main Methods:

  • A comprehensive literature search of published studies and conference proceedings was conducted.
  • Pivotal clinical trials investigating immune checkpoint inhibitors for cervical cancer were identified and analyzed.

Main Results:

  • Emerging data suggests that immune checkpoint inhibitors demonstrate potential in improving treatment response rates.
  • Evidence from key trials indicates a survival benefit for patients treated with ICIs in advanced cervical cancer settings.

Conclusions:

  • Immune checkpoint inhibitors represent a promising therapeutic avenue for locally advanced cervical cancer.
  • Further research and clinical trials are warranted to fully establish the role of ICIs in optimizing outcomes for cervical cancer patients.