Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

482
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
482
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

357
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
357
pre-mRNA Processing02:01

pre-mRNA Processing

57.6K
In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
57.6K
Pre-mRNA Processing: Modification of pre-mRNA Ends01:35

Pre-mRNA Processing: Modification of pre-mRNA Ends

15.3K
In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
15.3K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

480
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
480
Operational Amplifiers01:17

Operational Amplifiers

2.0K
The operational amplifier, often referred to as an op-amp, is a multifaceted building block of a circuit. This electronic component functions like a voltage-controlled voltage source and can also be used to create a voltage- or current-controlled current source. The design of an operational amplifier enables it to execute mathematical operations when external components like resistors and capacitors are linked to its terminals. An op-amp has the capacity to sum signals, amplify a signal,...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting "Ideal" Breast Proportionality to Support Implant Selection in Breast Augmentation.

Aesthetic plastic surgery·2026
Same author

Quantifying Breast Asymmetry Before and After Equal-Volume Subfascial Augmentation: the Volume-Shape Paradox.

Aesthetic plastic surgery·2026
Same author

Decellularized extracellular matrix enhances hydrogel printability for bioprinting functional muscle constructs in a volumetric muscle loss model.

Biomaterials·2026
Same author

Bridging ambition and evidence: The Australian Breast Device Registry comes of age.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

(Re)considering Discourses of Risk and Responsibility Through the Lens of Healthism: Interpreting the International Response to a Global Health Strategy for Noncommunicable Diseases.

Sociology of health & illness·2026
Same author

Tumor-Bearing Kidneys as Potential Donors: A National Survey From the United Kingdom.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2026

Related Experiment Video

Updated: Feb 6, 2026

Author Spotlight: Understanding the Effect of Herbal-Cake-Separated Moxibustion in Rats with Renal Faliure
06:46

Author Spotlight: Understanding the Effect of Herbal-Cake-Separated Moxibustion in Rats with Renal Faliure

Published on: December 22, 2023

1.2K

Renal failure parathyroidectomy - Is pre-operative imaging worthwhile?

Robert A J Spence1, Timothy J Patterson2, Peter Currie2

  • 1General Surgical Unit, Belfast City Hospital, 51 Lisburn Road, Belfast, BT9 7AB, Northern Ireland, United Kingdom.

The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
|August 12, 2018
PubMed
Summary

Preoperative imaging like ultrasound and isotope scans are more accurate for primary hyperparathyroidism surgery. Their use is limited in tertiary hyperparathyroidism surgery for renal failure patients.

Keywords:
HyperparathyroidismImagingMIBIPrimarySPECTTertiaryUltrasound

More Related Videos

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.3K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.3K

Related Experiment Videos

Last Updated: Feb 6, 2026

Author Spotlight: Understanding the Effect of Herbal-Cake-Separated Moxibustion in Rats with Renal Faliure
06:46

Author Spotlight: Understanding the Effect of Herbal-Cake-Separated Moxibustion in Rats with Renal Faliure

Published on: December 22, 2023

1.2K
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.3K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.3K

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Nephrology

Background:

  • Tertiary hyperparathyroidism is a common complication in renal failure patients requiring surgical intervention.
  • Preoperative imaging is standard for primary hyperparathyroidism but its utility in tertiary hyperparathyroidism is uncertain.
  • This study assesses the role of preoperative imaging in parathyroid surgery for both primary and tertiary hyperparathyroidism.

Purpose of the Study:

  • To evaluate the accuracy of preoperative imaging techniques in patients undergoing parathyroid surgery.
  • To compare the effectiveness of imaging in primary versus tertiary hyperparathyroidism.
  • To determine the clinical utility of preoperative imaging in renal failure patients with hyperparathyroidism.

Main Methods:

  • Prospective data collection over 10 years (2003-2013) from a single surgeon's practice.
  • Patients were categorized into primary hyperparathyroidism (49) and tertiary hyperparathyroidism (41) cohorts.
  • Combined ultrasound (US) and isotope (MIBI) imaging was performed in 70% of patients, with outcomes correlated to operative and pathological findings.

Main Results:

  • Ordinal regression analysis revealed significantly higher accuracy for imaging techniques in primary hyperparathyroidism compared to tertiary hyperparathyroidism (p=0.022).

Conclusions:

  • Combined US and MIBI preoperative imaging is essential for primary hyperparathyroidism surgery.
  • The diagnostic value of these imaging modalities is more limited in patients with tertiary hyperparathyroidism undergoing parathyroidectomy.
  • Clinical decision-making for parathyroid surgery in renal failure patients should consider the limitations of current preoperative imaging.