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High-performance, robustly verified Monte Carlo simulation with FullMonte.

Jeffrey Cassidy1, Ali Nouri1, Vaughn Betz1

  • 1Univ. of Toronto, Canada.

Journal of Biomedical Optics
|August 12, 2018
PubMed
Summary
This summary is machine-generated.

FullMonte is a new open-source software package for simulating light propagation in tissue. It offers high performance, extensive features, and a robust verification framework for biophotonics applications.

Keywords:
MCMLMonte Carlobioluminescence imagingdiffuse optical tomographyphotodynamic therapysimulation

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Area of Science:

  • Biophotonics and Biomedical Optics
  • Computational Physics and Simulation

Background:

  • Accurate simulation of light propagation in biological tissues is crucial for developing and validating optical technologies.
  • Existing Monte Carlo (MC) software packages may lack comprehensive features, high performance, or robust verification frameworks.

Purpose of the Study:

  • To introduce FullMonte, an open-source 3-D Monte Carlo software package for light propagation simulation in turbid media.
  • To provide a high-performance, feature-rich, and statistically verifiable tool for biophotonics research and education.

Main Methods:

  • Development of a tetrahedral mesh-based MC simulator with a focus on computational performance.
  • Implementation of a scripting interface for flexible simulation setup and parameter sweeps.
  • Integration with visualization tools (VTK, Paraview) and compatibility with other MC simulators (TIM-OS, MMC, COMSOL, MCML) for data exchange and comparison.
  • Establishment of a statistically justified framework for simulator verification and regression testing.

Main Results:

  • FullMonte demonstrates high computational performance and offers extensive input, output, and analysis capabilities.
  • The software supports publication-quality visualization and facilitates inter-simulator comparisons.
  • Demonstrated use cases include photodynamic therapy, bioluminescence imaging, and comparison with MCML for layered geometries.

Conclusions:

  • FullMonte provides a powerful, versatile, and rigorously verified open-source tool for light propagation simulation in biophotonics.
  • It serves diverse applications including therapeutic light delivery, imaging, diffuse optical tomography, and educational purposes.
  • The integrated verification framework addresses the unique challenges of validating stochastic MC simulations.