Related Experiment Video
Updated: Feb 6, 2026

Chemical Modification of the Tryptophan Residue in a Recombinant Ca2+-ATPase N-domain for Studying Tryptophan-ANS FRET
Published on: October 9, 2021
L-tryptophan administration and increase in cerebral serotonin levels: Systematic review
Isadora Braga Contreiras Carneiro1, Ana Elisa Toscano2, Diego Cabral Lacerda3
1Graduate Program in Nutrition, Federal University of Bahia, Av Araújo Pinho, 32 - Canela, 40110-150 Salvador, Bahia, Brazil; Center for Biological and Health Sciences, Federal University of Western Bahia, Estrada da Prainha s/n, 47805-000 Barreiras, Bahia, Brazil.
Abstract:
The amino acid tryptophan (2-Amino-3-(lH-indol-3-yl)-propanoic acid; Trp) is a precursor of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) that performs various brain functions. The administration of Trp is used in experimental studies to manipulate the serotonergic system, however the dose of Trp required to raise brain 5-HT levels is controversial. The aim of this study was to systemically review the effect of the administration of different doses of Trp on cerebral 5-HT levels. Two independent authors conducted a systematic review in the electronic databases. Twenty-five studies were included in the present review. Trp was administered orally, intraperitoneally or subcutaneous in adult animals. The brain 5-HT levels elevated after Trp administration in different intensities, dependent of the brain region evaluated and the time of administration. Further studies are needed to assess the dose-response of Trp administration to brain 5-HT levels.
More Related Videos
Related Concept Videos
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Increasing Function
Random and Systematic Errors
Systematic Sampling Method
Systematic sampling is one of the simplest methods...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
![Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F63025.jpg&w=3840&q=50)
