Related Experiment Video

Updated: Feb 6, 2026

Imaging of Estrogen Receptor-α in Rat Pial Arterioles using a Digital Immunofluorescent Microscope
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Imaging of Estrogen Receptor-α in Rat Pial Arterioles using a Digital Immunofluorescent Microscope

Published on: November 29, 2011

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Clinical Potential of Estrogen and Progesterone Receptor Imaging

Hannah M Linden1, Lanell M Peterson1, Amy M Fowler2

  • 1Department of Medical Oncology, Seattle Cancer Care Alliance, UWMC, 825 Eastlake Avenue East, Valley Building LV-200, Seattle, WA 98109-1023, USA.

PET Clinics
|August 14, 2018
PubMed

Insights

Molecular imaging with 16α-[18F]fluoro-17β-estradiol (FES) and other PET tracers shows promise for breast cancer patient prognosis and treatment response. A multicenter trial is advancing FES-PET imaging toward clinical use.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Molecular imaging with 16α-[18F]fluoro-17β-estradiol (FES) and 18F-fluoro-furanyl-norprogesterone PET assesses in vivo steroid hormone receptor function in breast cancer.
  • These experimental tracers have demonstrated potential in single-center trials for elucidating prognosis and predicting endocrine therapy response.

Purpose of the Study:

  • To advance the clinical use of FES-PET imaging through a current multicenter trial.
  • To explore the potential of these tracers in drug development, understanding estrogen receptor-positive tumor biology, and personalizing breast cancer treatment.

Main Methods:

  • Utilizing 16α-[18F]fluoro-17β-estradiol (FES) and 18F-fluoro-furanyl-norprogesterone for Positron Emission Tomography (PET) imaging.
  • Conducting a multicenter clinical trial to evaluate FES-PET imaging.

Main Results:

  • FES-PET imaging shows promise in assessing in vivo function of steroid hormone receptors in breast cancer.
  • Experimental agents have shown potential in predicting prognosis and endocrine therapy response in prior single-center trials.

Conclusions:

  • The multicenter trial of FES-PET imaging is a significant step toward its clinical application.
  • These molecular imaging tracers hold substantial potential for advancing breast cancer drug development, enhancing tumor biology understanding, and enabling personalized treatment strategies.
Keywords:
Breast cancerEstrogen receptor imagingFES-PETFFNP-PETProgesterone receptor imaging

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