Related Experiment Video

Updated: Feb 6, 2026

Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
09:16

Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy

Published on: September 11, 2015

8.7K

Clinical Potential of Human Epidermal Growth Factor Receptor 2 and Human Epidermal Growth Factor Receptor 3 Imaging

Kelly E Henry1, Gary A Ulaner2, Jason S Lewis3

  • 1Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

PET Clinics
|August 14, 2018
PubMed

Insights

Positron emission tomography (PET) imaging targeting human epidermal growth factor receptors (HER2 and HER3) aids breast cancer diagnosis and treatment response evaluation. This approach addresses tumor heterogeneity, offering a more precise understanding of disease progression and therapeutic efficacy.

Area of Science:

  • Oncology
  • Radiology
  • Molecular Imaging

Background:

  • Human epidermal growth factor receptor (HER) family proteins are key targets in breast cancer therapy and imaging.
  • Current diagnostic methods like repeat biopsies fail to capture tumor heterogeneity.
  • Targeting HER2 and HER3 offers specific, biologically relevant diagnostic and therapeutic avenues.

Purpose of the Study:

  • To highlight the utility of HER2- and HER3-targeted PET imaging in breast cancer.
  • To emphasize the role of PET in diagnosing breast cancer and assessing treatment response.
  • To underscore the importance of advanced imaging in understanding tumor behavior and treatment effectiveness.

Main Methods:

  • Utilizing positron emission tomography (PET) with radiolabeled biomolecules targeting HER2 and HER3.
  • Employing single photon emission computed tomography (SPECT) for target detection and quantification.
  • Analyzing the diagnostic and therapeutic implications of targeted molecular imaging.

Main Results:

  • HER2- and HER3-targeted PET can accurately diagnose breast cancer.
  • This imaging modality helps evaluate the response to targeted therapies.
  • PET imaging provides insights into intratumoral and metastatic heterogeneity.

Conclusions:

  • HER2- and HER3-targeted PET imaging is crucial for diagnosing breast cancer.
  • It serves as an important tool for monitoring treatment response.
  • Advanced imaging techniques improve the understanding of breast cancer biology and treatment outcomes.
Keywords:
Breast cancerCTHER2HER3MetastasisPETRadiotracersSPECT

More Related Videos

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells08:28

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

Published on: May 9, 2025

751
Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles08:35

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

Published on: January 4, 2012

28.7K

Related Concept Videos

Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.9K
Factors Influencing Microbial Growth: pH01:29

Factors Influencing Microbial Growth: pH

Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.2K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
Factors Influencing Microbial Growth: Temperature01:27

Factors Influencing Microbial Growth: Temperature

Microorganisms display remarkable adaptations, enabling them to thrive in diverse ecological niches across a wide range of temperatures. Temperature profoundly influences microbial growth by affecting enzymatic activity, membrane fluidity, and other cellular processes.Each microorganism operates within a specific temperature range defined by three cardinal points: minimum, optimum, and maximum. Below the minimum temperature, membranes lose fluidity, halting transport processes. Above the...
1.3K
Factors Influencing Microbial Growth: Osmolarity01:28

Factors Influencing Microbial Growth: Osmolarity

Osmolarity is the measure of solute concentration in a solution. It plays a critical role in determining water availability for organisms. Water moves across semipermeable membranes through osmosis, flowing from regions of lower solute concentration (more dilute) to regions of higher solute concentration (more concentrated).In high-solute environments, microbial cells lose water, leading to dehydration and inhibited growth. The extent to which water is available to microbes in such environments...
897
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.8K