Related Experiment Video
Updated: Feb 6, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
The structure-antioxidant activity relationship of dehydrodiferulates
Yuan Jia1, Ying He1, Fachuang Lu2
1State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
Abstract:
In this study, 11 dehydrodiferulic acids (DFAs) and 8 diethyl dehydrodiferulates (DEFs) were synthesized and evaluated by Trolox equivalent antioxidant capacity (TEAC) and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) assays for their antioxidant properties to understand the Structure-Antioxidant Activity Relationship (SAR) of these dehydrodiferulates. In both assays, the order of antioxidant activity for all tested ferulic acid dimers were consistent except for 3-(4-Hydroxy-3-methoxy-benzylidene)-5-(4-hydroxy-3-methoxy-phenyl)-3H-furan-2-one (2, 8-8-lactone DC DFA, not occurred naturally) being the best antioxidant by TEAC test. The order of antioxidant activity of diferulic acid ethyl esters, evaluated by both assays, was not consistent; however, TEAC and DPPH assays provided consistent results for certain set of ethyl diferulates. In this study most of dimeric ferulates, with three exceptions, showed higher radical-scavenging efficacy than the monomers. Comparing the antioxidant activities of the tested diferulates suggested that the phenolic hydroxyl group, electron donating methoxyl group, and stable conjugated transient structures dictate the antioxidant activity of diferulates.
More Related Videos
Related Concept Videos
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Local Anesthetics: Chemistry and Structure-Activity Relationship
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...

