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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Cell Adhesion Molecules - Types and Functions01:20

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Adhesion01:14

Adhesion

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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
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Cell Adhesion in Plants01:14

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
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Exercise Stress Test01:26

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Introduction
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An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
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Molecules and Compounds02:38

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Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
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Cell adhesion molecules and exercise.

Yunsuk Koh1, Jinkyung Park2

  • 1Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX, USA, yunsuk_koh@baylor.edu.

Journal of Inflammation Research
|August 14, 2018
PubMed
Summary
This summary is machine-generated.

Low-to-moderate aerobic exercise effectively reduces cell adhesion molecules (CAMs), markers of vascular inflammation. High-intensity aerobic exercise causes a temporary increase, while resistance exercise shows no significant effect on CAMs.

Keywords:
ICAM-1VCAM-1atherosclerosiscardiovascular diseasesendothelial dysfunctioninflammation

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Area of Science:

  • Exercise Physiology
  • Cardiovascular Health
  • Molecular Biology

Background:

  • Cell adhesion molecules (CAMs) are key indicators of vascular inflammation, endothelial dysfunction, and atherosclerosis.
  • Understanding exercise's impact on CAMs is crucial for managing cardiovascular health.
  • This review explores exercise's role in modulating CAMs.

Purpose of the Study:

  • To systematically review the literature on exercise type and intensity effects on CAMs.
  • To analyze the impact of aerobic versus resistance exercise on specific CAMs.
  • To investigate the influence of exercise intensity on CAM expression.

Main Methods:

  • Systematic review of 28 qualifying studies.
  • Analysis of exercise interventions based on intensity (low-to-moderate vs. high) and type (aerobic vs. resistance).
  • Examination of effects on intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and selectins.

Main Results:

  • Low-to-moderate intensity aerobic exercise demonstrated a favorable decrease in CAMs across various populations.
  • High-intensity aerobic exercise led to a transient increase in CAMs, returning to baseline within hours.
  • Resistance exercise, irrespective of intensity, did not significantly alter CAM levels.

Conclusions:

  • Exercise-induced changes in CAMs are dependent on both type and intensity.
  • Low-to-moderate aerobic exercise is most effective in reducing CAMs, indicating improved vascular health.
  • Further research on exercise, CAMs, and cytokines is needed to optimize exercise programming for vascular health.