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Updated: Feb 6, 2026
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
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ASGART: fast and parallel genome scale segmental duplications mapping.
Franklin Delehelle1,2, Sylvain Cussat-Blanc1, Jean-Marc Alliot1
1UMR5505 - CNRS-Université de Toulouse, Institut de Recherche en Informatique de Toulouse (IRIT), Toulouse, France.
Bioinformatics (Oxford, England)
|August 14, 2018
Summary
A new tool, ASGART, efficiently detects segmental duplications (SDs) in genomes. This software addresses challenges in sequencing duplicated regions, aiding comparative genomics and understanding genomic evolution.
Area of Science:
- Genomics
- Bioinformatics
- Evolutionary Biology
Background:
- Segmental duplications (SDs) are crucial for genomic fluidity but difficult to sequence and analyze.
- Advancements in sequencing technologies necessitate efficient tools for SD detection.
Purpose of the Study:
- To introduce ASGART, an open-source tool for identifying segmental duplications in assembled genomes.
- To provide a solution for the growing need for SD analysis in newly sequenced genomes.
Main Methods:
- ASGART was developed to search for segmental duplications in any assembled sequence.
- The tool was tested and benchmarked on five model organisms.
Main Results:
- ASGART successfully extracts SDs from genome-wide sequences of varying sizes and complexity.
- The software demonstrates superior speed compared to existing detection tools.
Conclusions:
- ASGART is an efficient and fast solution for segmental duplication detection.
- The tool supports comparative genomics by enabling retrieval and comparison of SDs across species.
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