Related Experiment Video

Updated: Feb 6, 2026

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
09:38

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Published on: June 26, 2019

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An EGFR-mutated Lung Adenocarcinoma Undergoing Squamous Cell Carcinoma Transformation Exhibited a Durable Response to

Mitsuo Sato1, Akira Matsui1, Yoshie Shimoyama2

  • 1Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|August 14, 2018
PubMed

Insights

Squamous cell carcinoma transformation can cause resistance to EGFR-TKIs in lung cancer. Afatinib, a second-generation TKI, showed a durable response in an EGFR-mutated lung adenocarcinoma undergoing this transformation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • First-generation EGFR-TKIs (gefitinib, erlotinib) face resistance via squamous cell carcinoma (SCC) transformation in EGFR-mutated lung cancer.
  • The efficacy of newer-generation TKIs against SCC transformation is not well-established.

Observation:

  • A case of EGFR-mutated lung adenocarcinoma is presented.
  • This tumor underwent transformation into squamous cell carcinoma.

Findings:

  • The transformed tumor exhibited a sustained response to afatinib, a second-generation irreversible EGFR-TKI.
  • This response occurred despite the SCC transformation, a known resistance mechanism.

Implications:

  • Afatinib may be a viable treatment option for EGFR-mutated lung tumors that transform into SCC.
  • This is particularly relevant when the T790M resistance mutation is absent.
Keywords:
EGFR mutationafatiniberlotinibsquamous cell carcinoma transformation

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