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Updated: Feb 6, 2026
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
Prospective comparison between DCE-MRR and 99m Tc-DTPA-based SPECT for determination of allograft renal function
Zhou Wan-Li1, Tao Jun1, Zhang Yu-Dong2
1Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background:
Glomerular filtration rate (GFR) is a preferred indicator of allograft renal function, but direct measurement of GFR remains complicated.
Purpose:
To prospectively compare dynamic contrast-enhanced MR renography (DCE-MRR) with 99m Tc-DTPA-based single-photon emission computed tomography (SPECT) for determination of allograft renal function.
Study Type:
Prospective.
Population:
Seventy kidney-transplant recipients FIELD STRENGTH: A low-dose DCE-MRR with a 3.0T scanner and a 99m Tc-DTPA-based SPECT after renal transplantation were performed.
Assessment:
A Baumann-Rudin (BR) and a modified two-compartment model (JZ2C) were used for DCE-MRR analysis. Standard Gate's method was used for SPECT analysis. An endogenous creatinine clearance rate (CCr) constituted the reference standard.
Statistical Tests:
Pearson correlation test and Bland-Altman agreement analysis.
Results:
The reference CCr-GFR was 59.58 ± 23.72 mL/min/1.73 m2 . GFR determined by eGFR, BR, JZ2C, and SPECT was 90.22 ± 34.38, 36.78 ± 14.46, 48.99 ± 23.88, and 67.32 ± 18.44 mL/min/1.73 m2 , respectively. DCE-MRR using JZ2C had the best overall performance, with a Pearson correlation coefficient of 0.81, a bias of -10.58 mL/min/1.73 m2 , and a precision of 14.61 mL/min/1.73 m2 , as well as high accuracy (30-50% intervals: 74.3-90.0%). Although SPECT had a small bias (7.74 mL/min/1.73 m2 ), it had a poor correlation coefficient (0.38), poor precision (23.93 mL/min/1.73 m2 ), and low accuracy (64.3-72.3%) as compared with DCE-MRR using JZ2C.
Data Conclusion:
DCE-MRR using JZ2C is superior to 99m Tc-DTPA-based SPECT to determine allograft renal function.
Level Of Evidence:
2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:262-269.
Insights
Dynamic contrast-enhanced MR renography (DCE-MRR) using the JZ2C model is superior to SPECT for assessing kidney transplant function. This advanced MR technique offers better accuracy and precision in determining allograft renal function compared to traditional SPECT imaging.
Area of Science:
- Radiology and Imaging Science
- Nephrology and Urology
- Transplant Medicine
Background:
- Glomerular filtration rate (GFR) is crucial for monitoring kidney allograft function.
- Accurate GFR measurement is essential but technically challenging.
Purpose of the Study:
- To prospectively compare dynamic contrast-enhanced MR renography (DCE-MRR) with 99mTc-DTPA-based SPECT.
- To evaluate the efficacy of these methods in determining allograft renal function.
Main Methods:
- Seventy kidney transplant recipients underwent low-dose DCE-MRR (3.0T scanner) and 99mTc-DTPA-based SPECT.
- DCE-MRR analysis used Baumann-Rudin (BR) and modified two-compartment (JZ2C) models.
- SPECT analysis employed Standard Gate's method; endogenous creatinine clearance (CCr) served as the reference standard.
Main Results:
- DCE-MRR with the JZ2C model demonstrated superior performance (correlation coefficient 0.81, bias -10.58 mL/min/1.73 m², precision 14.61 mL/min/1.73 m²).
- SPECT showed a weaker correlation (0.38), larger precision (23.93 mL/min/1.73 m²), and lower accuracy compared to DCE-MRR JZ2C.
- The reference CCr-GFR was 59.58 ± 23.72 mL/min/1.73 m².
Conclusions:
- DCE-MRR, particularly using the JZ2C model, is a more accurate and precise method for assessing allograft renal function than 99mTc-DTPA-based SPECT.
- This finding supports the clinical utility of advanced MR renography techniques in post-transplant monitoring.
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