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Updated: Feb 6, 2026
05:57
Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
Published on: August 2, 2022
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Platelet-Rich Plasma Augments Subcision in Atrophic Acne Scars: A Split-Face Comparative Study.
Nitika S Deshmukh1, Vasudha A Belgaumkar2
1*Both authors are affiliated with the Department of Dermatology, Byramjee Jeejeebhoy Government Medical College, Pune, India.
Summary
Autologous platelet-rich plasma (PRP) combined with subcision significantly improves acne scars more than subcision alone. This novel treatment offers a synergistic approach for better scar revision outcomes.
Area of Science:
- Dermatology
- Regenerative Medicine
- Aesthetic Procedures
Background:
- Acne affects 90% of adolescents, with 75% experiencing facial scarring.
- Autologous platelet-rich plasma (PRP) is an emerging treatment for acne scar management.
- PRP can be used as an adjuvant therapy to enhance acne scar revision procedures.
Purpose of the Study:
- To compare the efficacy of autologous PRP combined with subcision versus subcision alone for treating acne scars.
- To evaluate the effectiveness of PRP as an adjuvant therapy in acne scar revision.
Main Methods:
- An experimental analytical, split-face study conducted over two years with 40 participants.
- One side of the face received subcision with autologous PRP injection, while the other (control) side received subcision only.
- Digital photography and statistical analysis using Wilcoxon signed-rank and Mann-Whitney tests were employed.
Main Results:
- Combined PRP and subcision demonstrated significantly greater improvement (32.08%) compared to subcision alone (8.33%).
- Rolling acne scars showed the highest response rate (39.27%), followed by box-type scars (33.88%).
Conclusions:
- Autologous PRP and subcision act synergistically to improve the appearance of acne scars.
- PRP as an adjuvant therapy reduces the number of sittings required for effective scar remodeling.
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