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Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

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Published on: July 1, 2015

Resilience and immunity.

Robert Dantzer¹, Sheldon Cohen², Scott J Russo³

¹The University of Texas MD Anderson Cancer Center, Houston, TX 77005, USA.

Brain, Behavior, and Immunity

|August 14, 2018

Summary

This summary is machine-generated.

Resilience, the ability to adapt to stress, is linked to immunity. Individual immune profiles influence stress resilience, and interventions targeting the gut microbiota may offer future therapeutic avenues.

Keywords:

CD8 T cells Cytokines Depression Gut microbiota Gut-brain axis Immunity Indoleamine 2,3 dixoygenase Inflammation Optimism Personal control Positive affect Psychobiotics Recovery Resilience Social support Stress

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Area of Science:

Psychoneuroimmunology
Stress Physiology
Behavioral Science

Background:

Resilience involves adapting to adverse conditions, supported by personal control, optimism, and social support.
Biopsychosocial factors protect against stressor impacts on physiology and immunity.
Immune processes reciprocally influence resilience, particularly in chronic stress responses.

Purpose of the Study:

To explore the bidirectional relationship between resilience and immunity.
To investigate how immune phenotypes differ between resilient and stress-susceptible individuals.
To examine the potential of modulating resilience and immunity via the gut microbiota.

Main Methods:

Review of animal and human studies on stress, immunity, and resilience.
Analysis of immunophenotypic differences in resilient versus susceptible individuals.
Exploration of gut microbiota's role in modulating resilience-immunity interactions.

Main Results:

Resilient individuals exhibit distinct immunophenotypes compared to stress-susceptible individuals.
Inflammatory phenotypes can be altered to influence resilience.
The adaptive immune system impacts recovery from inflammation-induced symptoms.

Conclusions:

Immunity and resilience share a complex, bidirectional relationship.
Modulating the gut microbiota with probiotics/prebiotics presents a potential strategy for influencing resilience and immunity.
Further research is needed to translate these findings into practical applications.