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Increased maternal C1q/TNF-related protein-1 (CTRP-1) serum levels in pregnancies with preeclampsia

Deniz Acar1, Ahmet Tayyar1, Aytac Yuksel1

  • 1Maternal Fetal Medicine Unit, Health Sciences University Kanuni Sultan Suleyman Education and Research Hospital, Istanbul, Turkey.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|August 15, 2018
PubMed

Insights

Serum levels of Complement C1q tumor necrosis factor-related protein-1 (CTRP-1) were elevated in women with preeclampsia. Higher CTRP-1 correlated with increased blood pressure and decreased gestational age and birth weight in these pregnancies.

Area of Science:

  • Reproductive biology
  • Endocrinology
  • Biochemistry

Background:

  • Preeclampsia pathogenesis involves metabolic changes and inflammation.
  • Complement C1q tumor necrosis factor-related protein-1 (CTRP-1) influences insulin sensitivity, lipid metabolism, and inflammation.

Purpose of the Study:

  • To investigate serum CTRP-1 levels in pregnancies complicated by preeclampsia.

Main Methods:

  • Serum CTRP-1 concentrations were measured using ELISA.
  • Study groups included early-onset preeclampsia (EOPE), late-onset preeclampsia (LOPE), and uncomplicated pregnancies.

Main Results:

  • Significantly higher serum CTRP-1 levels were observed in both EOPE and LOPE groups compared to controls.
  • No significant difference in CTRP-1 levels was found between EOPE and LOPE groups.
  • CTRP-1 levels positively correlated with systolic and diastolic blood pressure and mean UtA PI.
  • CTRP-1 levels negatively correlated with gestational age at delivery and birth weight.

Conclusions:

  • Serum CTRP-1 levels are significantly elevated in preeclampsia.
  • CTRP-1 may play a role in the pathophysiology of preeclampsia.

Keywords:
CTRP-1dyslipidemiaearly onset preeclampsiainflammationinsulin resistancelate onset preeclampsia

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