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Author Spotlight: RNAi Inheritance and ChIP in C. elegans

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Transgenerational Epigenetic Mechanisms in Adipose Tissue Development.

Simon Lecoutre¹, Paul Petrus², Mikael Rydén²

¹University of Lille, EA4489, Equipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F-59000 Lille, France; Department of Medicine (H7), Karolinska Institutet, 141 86 Stockholm, Sweden.

Trends in Endocrinology and Metabolism: TEM

|August 15, 2018

Summary

Maternal malnutrition impacts offspring adipose tissue, increasing obesity risk across generations. Epigenetic changes in adipose tissue are key to these inherited metabolic disruptions.

Keywords:

Developmental Origin of Health and Disease fat expansion maternal obesity perinatal period programming

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Area of Science:

Metabolic diseases
Nutritional science
Epigenetics

Background:

Perinatal malnutrition increases adult metabolic disease risk, including obesity.
Offspring adipose tissue (AT) shows altered adipogenesis, lipogenesis, adipokine expression, thermogenesis, and inflammation.
Epigenetic mechanisms are implicated in these transgenerational effects.

Purpose of the Study:

To review epigenetic mechanisms in adipose tissue that regulate adipocyte formation and function.
To explore how maternal diet influences offspring AT epigenetic regulation.
To inform preventive strategies against obesity.

Main Methods:

Literature review focusing on epigenetic mechanisms in adipose tissue.
Analysis of studies investigating maternal diet effects on offspring AT.
Synthesis of current understanding of transgenerational metabolic dysregulation.

Main Results:

Epigenetic modifications in offspring AT are linked to maternal nutritional status.
These modifications can alter adipocyte development and function across generations.
Specific epigenetic pathways involved in AT regulation are highlighted.

Conclusions:

Epigenetic regulation of adipose tissue plays a critical role in transgenerational inheritance of metabolic dysfunction.
Understanding these mechanisms is vital for developing interventions against the obesity pandemic.
Targeting maternal nutrition and epigenetic pathways may offer novel preventive strategies.