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Some immunological parameters in rheumatoid arthritis from India
Biomedicine / [Publiee Pour L'A.A.I.C.I.G.]
|March 1, 1977
Summary
Indian rheumatoid arthritis patients show altered immune responses, including high immunoglobulins and a significant rise in IgM after TAB vaccination, potentially linked to increased rheumatoid factor. Further research is needed.
Area of Science:
- Immunology
- Rheumatology
- Clinical Medicine
Background:
- Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting joints.
- Immune system dysregulation is central to RA pathogenesis.
- Understanding the immune status in diverse populations like Indian RA patients is crucial.
Purpose of the Study:
- To investigate the immune status of rheumatoid arthritis patients from India.
- To assess cellular and humoral immune responses in these patients.
- To evaluate the effect of TAB vaccination on immune markers in RA.
Main Methods:
- Analysis of immunoglobulin levels, C3 complement, and autoantibodies (seropositivity, antinuclear antibody).
- Assessment of T lymphocyte proportion and delayed hypersensitivity skin tests (Mantoux, streptokinase-streptodornase).
- Evaluation of humoral antibody response to TAB vaccine and changes in rheumatoid factor (RF).
Main Results:
- Patients exhibited high immunoglobulin levels and 26% tested positive for antinuclear antibody.
- Delayed hypersensitivity skin tests were positive in approximately 50% of patients compared to controls.
- TAB vaccination led to a significant rise in IgM levels and rheumatoid factor in RA patients, with some converting to seropositive status.
Conclusions:
- Indian RA patients display distinct immunological features compared to Western cohorts.
- Cellular immunity may be moderately impaired, while humoral responses show specific alterations.
- TAB vaccination can exacerbate immune responses in RA patients, particularly concerning rheumatoid factor production.