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Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community

Tomohiro Yubi1, Jun Hata1, Tomoyuki Ohara1

  • 1Departments of Epidemiology and Public Health (TY, JH, DY, YF, TN), Department of Neuropsychiatry (TO), Center for Cohort Studies (NM), Department of Medicine and Clinical Sciences (YH, SG, TA, TK), and Department of Psychosomatic Medicine (NH), Graduate School of Medical Sciences, Kyushu University, Fukuoka; and Hisayama Research Institute for Lifestyle Diseases (YK), Fukuoka, Japan.

Neurology. Clinical Practice
|August 15, 2018
PubMed
Abstract

Insights

Approximately 1 in 5 elderly Japanese individuals have cerebral microbleeds (CMBs). Risk factors differ for deep versus lobar CMBs, suggesting distinct causes for these brain lesions.

Area of Science:

  • Neurology
  • Geriatrics
  • Radiology

Background:

  • Investigated prevalence and risk factors of cerebral microbleeds (CMBs) in Japanese elderly.
  • Cross-sectional study of a general population aged 65+.

Purpose of the Study:

  • Determine the prevalence of cerebral microbleeds (CMBs) in Japanese elderly.
  • Identify traditional cardiovascular risk factors and APOE polymorphism associated with CMBs.

Main Methods:

  • Brain MRI (1.5T) and health examinations for 1281 residents.
  • Defined CMBs (<10mm lesions on T2*-weighted images) and classified them as deep/infratentorial or lobar.
  • Logistic regression analysis to assess associations with risk factors and APOE genotype.

Main Results:

  • Crude prevalence: 18.7% total CMBs, 13.5% deep/infratentorial, 9.6% lobar.
  • Prevalence increased with age and was higher in men (23.0%) than women (15.5%).
  • Hypertension linked to both CMB types; low cholesterol to deep CMBs; APOE ε4 to lobar CMBs.

Conclusions:

  • About 1 in 5 Japanese elderly have CMBs.
  • Distinct risk factors for deep/infratentorial and lobar CMBs suggest different underlying pathologies.
  • Highlights the need for targeted risk factor management based on CMB location.

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