Related Experiment Video

Updated: Feb 6, 2026

Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials
06:24

Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials

Published on: January 11, 2020

6.7K

Obstetric Anti-phospholipid Syndrome: State of the Art

Maria Chiara Gerardi1, Melissa Alexandre Fernandes2, Angela Tincani1

  • 1Rheumatology and Clinical Immunology Unit and Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy.

Current Rheumatology Reports
|August 15, 2018
PubMed

Insights

Obstetric anti-phospholipid syndrome (ob-APS) involves inflammation and poor pregnancy outcomes. Conventional treatments improve outcomes for 70% of women, while new therapies are explored for refractory cases.

Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Rheumatology

Background:

  • Obstetric anti-phospholipid syndrome (ob-APS) is a significant cause of adverse pregnancy outcomes.
  • Its pathogenesis involves placental infarction and inflammatory cell infiltration, leading to uncontrolled inflammation.

Purpose of the Study:

  • To review recent advancements in the pathogenesis and clinical-therapeutic strategies for obstetric anti-phospholipid syndrome (ob-APS).
  • To highlight the importance of preconception counseling and tailored treatment for improving maternal and fetal outcomes in ob-APS patients.

Main Methods:

  • Literature review focusing on studies published within the last five years.
  • Analysis of current understanding of ob-APS pathogenesis and treatment modalities.

Main Results:

  • Conventional treatment (low-dose aspirin and heparin) achieves successful pregnancies in approximately 70% of women with ob-APS.
  • Investigational therapies like hydroxychloroquine, statins, and eculizumab show promise for patients resistant to standard care.
  • Further investigation is needed for managing 'aPL carriers' and patients with obstetric manifestations not meeting full ob-APS criteria.

Conclusions:

  • Patient-tailored management and preconception counseling are crucial for optimizing outcomes in ob-APS.
  • While conventional therapies are effective for many, novel therapeutic agents are being explored for challenging cases.
  • Continued research is essential to refine management strategies for all patients affected by obstetric anti-phospholipid syndrome.
Abstract

Keywords:
Anti-phospholipid antibodiesAnti-phospholipid syndromeManagementObstetric complicationsPathogenesisPregnancy morbidityTreatment

More Related Videos

A Fluorescence-based Assay of Phospholipid Scramblase Activity09:52

A Fluorescence-based Assay of Phospholipid Scramblase Activity

Published on: September 20, 2016

14.7K
X-ray Powder Diffraction in Conservation Science: Towards Routine Crystal Structure Determination of Corrosion Products on Heritage Art Objects09:16

X-ray Powder Diffraction in Conservation Science: Towards Routine Crystal Structure Determination of Corrosion Products on Heritage Art Objects

Published on: June 8, 2016

16.8K

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
661
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.0K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.0K
Waterproofing and Anti-Bacterial Admixtures in Concrete01:22

Waterproofing and Anti-Bacterial Admixtures in Concrete

Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
244
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
573
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
344