[Changes in the serotonin metabolism of rats with neurodystrophic process]

Some mechanisms of alteration in serotonin content in tissues and an effect of the amine on development of visible trophic impairment in rats were studied under conditions of neurodystrophic impairments which occurred in the animals as a result of chronic stimulation of sciatic nerve. A long-term increase in serotonin content in tissues of rats with the neurodystrophic process was due to activation of its synthesis. Elevation in serotonin content in animals under conditions of chronic stimulation of peripheral nervous system might be of importance for development of neural and neurogenic dystrophies.