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[Cyclic nucleotides in multiple sclerosis].

O A Khondkarian, T S Korshunova, E G Larskiĭ

    Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
    |January 1, 1986
    PubMed
    Summary

    This study found elevated cyclic adenosine monophosphate (cAMP) in patients with multiple sclerosis, particularly in advanced disease stages. cAMP levels fluctuated more during disease flare-ups compared to remission.

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    [Compensatory mechanisms in multiple sclerosis(review)].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2013

    Area of Science:

    • Neuroimmunology
    • Biochemistry
    • Clinical Neurology

    Context:

    • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
    • Cyclic nucleotides like cAMP and cGMP play crucial roles in cellular signaling and immune regulation.
    • Understanding biochemical markers in MS is vital for diagnosis and monitoring disease progression.

    Purpose:

    • To investigate the concentrations and ratio of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in blood plasma and cerebrospinal fluid (CSF).
    • To correlate these cyclic nucleotide levels with different forms and disease durations of multiple sclerosis.
    • To analyze the variability of cAMP levels during exacerbation and remission phases of MS.

    Summary:

    • Elevated cyclic adenosine monophosphate (cAMP) concentrations were observed in both plasma and cerebrospinal fluid (CSF) of all 83 multiple sclerosis patients studied.
    • The elevation in cAMP was more pronounced in patients with long-standing and disseminated forms of the disease.
    • Blood plasma levels of cAMP exhibited greater variability during periods of disease exacerbation compared to remission.

    Impact:

    • This research highlights cAMP as a potential biomarker for multiple sclerosis disease activity and progression.
    • Findings may contribute to a better understanding of the pathophysiology of multiple sclerosis.
    • The study provides insights into the dynamic changes of cyclic nucleotides in relation to MS disease course.

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