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Updated: Feb 6, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Light-Driven Enzymatic Decarboxylation of Fatty Acids
Mieke M E Huijbers1, Wuyuan Zhang1, Fabio Tonin1
1Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629, HZ, Delft, The Netherlands.
Abstract:
The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversible preparation of alkanes from fatty acids and triglycerides. Several fatty acids and their triglycerides are converted by CvFAP in near-quantitative yield and exclusive selectivity upon illumination with blue light. Very promising turnover numbers of up to 8000 were achieved in this proof-of-concept study.
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