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Engineering Antiviral Agents via Surface Plasmon Resonance
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Phase-sensitivity-doubled surface plasmon resonance sensing via self-mixing interference.

Pan Qi, Bowen Zhou, Zibang Zhang

    Optics Letters
    |August 15, 2018
    PubMed
    Summary

    A new self-mixing interference (SMI) approach simplifies surface plasmon resonance (SPR) sensing. This method doubles phase sensitivity, offering a compact, robust, and commercially viable alternative to complex conventional SPR systems.

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    Area of Science:

    • Optics
    • Nanotechnology
    • Chemical Sensing

    Background:

    • Conventional phase-based surface plasmon resonance (SPR) sensing offers high sensitivity (10⁻⁸ RIU) but suffers from complex setups due to two-beam interference.
    • These complexities hinder commercialization, demanding improved anti-noise capabilities and stable working conditions.

    Purpose of the Study:

    • To develop a simplified, compact, and highly sensitive SPR sensing approach.
    • To overcome the limitations of conventional SPR systems for practical applications.

    Main Methods:

    • Implementation of a self-mixing interference (SMI) technique for SPR sensing.
    • Utilizing a single optical path to enhance simplicity and reduce device complexity.
    • Designing a setup where light phase changes twice, effectively doubling phase sensitivity.

    Main Results:

    • Demonstrated a compact and simple experimental setup for SPR sensing.
    • Achieved doubled phase sensitivity compared to conventional methods.
    • Experimental results for NaCl solution refractive index changes align with theoretical and simulation predictions.

    Conclusions:

    • The proposed SMI-based SPR sensing approach offers a significant advancement over conventional methods.
    • This technique provides a robust, compact, and sensitive platform suitable for commercial SPR sensing applications.