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β-Cyclodextrin-Functionalized Chitosan/Alginate Compact Polyelectrolyte Complexes (CoPECs) as Functional Biomaterials
Alexandre Hardy1, Cendrine Seguin1, Anaïs Brion1
1Faculté de Pharmacie , Université de Strasbourg, CNRS, Laboratoire de Conception et Application de Molécules Bioactives UMR 7199 , 74 route du Rhin , 67401 Illkirch Cedex, France.
ACS Applied Materials & Interfaces
|August 15, 2018
Summary
A novel biomaterial, β-cyclodextrin-functionalized chitosan/alginate Compact Polyelectrolyte Complexes (CoPECs), shows intrinsic anti-inflammatory effects. This drug carrier effectively reduces inflammatory markers and could treat chronic diseases.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Immunology
Background:
- Increasing demand for therapeutic biomaterials with anti-inflammatory properties.
- Compact polyelectrolyte complexes (CoPECs) are a novel class of materials formed via ultracentrifugation.
- Chitosan and alginate are biocompatible polymers with potential in therapeutic applications.
Purpose of the Study:
- To formulate and characterize a noncytotoxic β-cyclodextrin-functionalized chitosan/alginate CoPEC.
- To evaluate the CoPEC as a drug carrier for hydrophobic drugs.
- To investigate the intrinsic anti-inflammatory properties of the developed CoPEC.
Main Methods:
- Formulation of β-cyclodextrin-functionalized chitosan/alginate CoPECs.
- Characterization of CoPEC structure and properties.
- In vitro assessment of anti-inflammatory activity using murine macrophages stimulated with lipopolysaccharide (LPS).
- Drug entrapment and release studies using piroxicam as a model drug.
Main Results:
- Successful formation of a noncytotoxic β-cyclodextrin-functionalized chitosan/alginate CoPEC.
- CoPEC demonstrated effective trapping and release of hydrophobic drugs (piroxicam).
- The CoPEC significantly inhibited LPS-induced TNF-α and nitric oxide (NO) release in macrophages.
- CoPEC moderated the differentiation of LPS-activated macrophages, indicating immunomodulatory effects.
Conclusions:
- The developed CoPEC is a promising bioactive biomaterial with intrinsic anti-inflammatory properties.
- This CoPEC can serve as an effective drug delivery system for hydrophobic drugs.
- This new class of therapeutic biomaterials holds potential for treating chronic inflammatory diseases like arthritis and Crohn's disease.
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