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Updated: Jul 16, 2026

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

Molecular mechanisms of platelet aggregation

L Leung, R Nachman

    Annual Review of Medicine
    |January 1, 1986
    PubMed

    Recent studies suggest that platelet stimulation leads to the induction of specific fibrinogen receptors, which have been identified as the platelet membrane glycoprotein IIb-IIIa complex. The binding of fibrinogen initiates the reversible primary phase of aggregation. With a strong stimulus, thrombospondin is released from the platelet alpha-granules. By interacting with fibrinogen, thrombospondin serves to stabilize the platelet aggregates, which leads to a secondary irreversible phase of aggregation.

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