Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

3.5K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.5K
Introduction to Urinary System01:13

Introduction to Urinary System

9.1K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
9.1K
Disorders of the Urinary System01:20

Disorders of the Urinary System

1.2K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
1.2K
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

1.7K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.7K
Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

545
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
545
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

698
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
698

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial transcriptomic map of the mouse urinary bladder.

Scientific reports·2026
Same author

Precision targeting of STING: Challenges, innovations, and clinical outlook for cancer therapy.

Innovation (Cambridge (Mass.))·2026
Same author

DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality.

Science (New York, N.Y.)·2026
Same author

The Potential Role of Vitamin D in the Pterygium Pathophysiology-A Possible New Therapeutic Perspective and Narrative Review.

Journal of clinical medicine·2025
Same author

Potential Role of <i>Malassezia restricta</i> in Pterygium Development.

International journal of molecular sciences·2025
Same author

Urinary microbiota changes among NMIBC patients during BCG therapy: comparing BCG responders and non-responders.

Frontiers in cellular and infection microbiology·2025

Related Experiment Video

Updated: Feb 6, 2026

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

1.2K

The urinary microbiome associated with bladder cancer.

Viljemka Bučević Popović1, Marijan Šitum2, Cheryl-Emiliane T Chow3

  • 1University of Split, Faculty of Science, Department of Chemistry, Split, Croatia.

Scientific Reports
|August 16, 2018
PubMed
Summary

The human urinary microbiome may play a role in bladder cancer. Researchers found Fusobacterium enriched in bladder cancer patients, suggesting a potential link between this bacterium and the disease.

More Related Videos

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.4K
Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.5K

Related Experiment Videos

Last Updated: Feb 6, 2026

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

1.2K
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.4K
Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.5K

Area of Science:

  • Microbiology
  • Oncology
  • Urology

Background:

  • The human microbiome's influence on cancer development is increasingly recognized.
  • The specific role of microorganisms in bladder cancer pathogenesis remains largely unexplored.

Purpose of the Study:

  • To characterize and compare the urinary microbiome composition in bladder cancer patients versus healthy controls.
  • To identify specific microbial signatures associated with bladder cancer.

Main Methods:

  • 16S rRNA gene sequencing was used to analyze bacterial communities in urine samples from 12 male bladder cancer patients and 11 age-matched healthy controls.
  • Polymerase chain reaction (PCR) was employed to detect Fusobacterium nucleatum in an independent cohort of 42 bladder cancer tissues.

Main Results:

  • The most abundant bacterial phyla in both groups were Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria.
  • While overall microbial diversity and composition were similar, specific operational taxonomic units (OTUs) differed between groups.
  • An OTU belonging to the genus Fusobacterium was significantly enriched in the bladder cancer group, and F. nucleatum was detected in 11 of 42 bladder cancer tissues.
  • OTUs from Veillonella, Streptococcus, and Corynebacterium genera were more abundant in healthy urine samples.

Conclusions:

  • The urinary microbiome may be altered in bladder cancer patients, with a potential enrichment of Fusobacterium.
  • Further research with larger sample sizes is necessary to confirm the association between urinary microbiome alterations and bladder cancer development.