Physiological Uptake of F18-FDG in breast parenchyma

Increased F18-FDG uptake is on PET-CT images should always be assessed carefully for physiological and pathological causes. Breast uptake may be focal or diffuse. Although propensity of tumours increase in focal uptake; diffuse involvement may be seen in lymphoma and some types of breast cancer. Frequently, diffuse breast uptake is non-pathologic due to infection, physiological uptake or lactation. We describe the case of a 27-years old female who underwent 18F FDGPET-CT scan for staging workup of diffuse large B-cell lymphoma (DLBCL). The scan demonstrated bilateral F18-FDG breast uptake, due to ongoing lactation.