Related Experiment Video
Updated: Aug 4, 2026
07:18
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Published on: June 13, 2019
Cystosarcoma phyllodes of the prostate. A pathologic and immunohistochemical study
Archives of Pathology & Laboratory Medicine
|June 1, 1986
Summary
Prostate lesions resembling breast cystosarcoma phyllodes were treated successfully in two patients. These rare tumors showed distinct epithelial and stromal components with favorable outcomes post-surgery.
Area of Science:
- Uropathology
- Oncology
- Surgical Pathology
Background:
- Cystosarcoma phyllodes typically occurs in the breast.
- Prostate lesions with similar histologic features are rare and poorly understood.
- Understanding the nature of these prostate tumors is crucial for diagnosis and treatment.
Observation:
- Two patients presented with prostate lesions exhibiting histologic similarities to breast cystosarcoma phyllodes.
- One lesion showed stromal progression to sarcoma, while the other had a mitotically inactive stroma.
- Immunohistochemistry revealed distinct markers for stromal (vimentin, desmin) and epithelial (prostate-specific antigen, epithelial membrane antigen) components.
Findings:
- The stromal component was immunoreactive for vimentin and desmin but negative for epithelial markers.
- The epithelial component showed reactivity for prostate-specific antigen and epithelial membrane antigen.
- Both patients experienced successful surgical resection with no recurrence or metastasis at 2-3 years post-operation.
Implications:
- These findings highlight the existence of rare prostate tumors mimicking breast cystosarcoma phyllodes.
- Successful surgical management suggests a potentially favorable prognosis for these specific prostate lesions.
- Further research into the histogenesis of these tumors is warranted to improve understanding and diagnostic criteria.
