Related Experiment Video

Updated: Feb 6, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K

The use of methotrexate for treating childhood atopic dermatitis: a multicenter retrospective study

Yossi Taieb1,2, Sharon Baum1,2, Dan Ben Amitai2,3

  • 1a Dermatology Department , Sheba Medical Center , Ramat Gan , Israel.

The Journal of Dermatological Treatment
|August 16, 2018
PubMed

Insights

Methotrexate effectively treats severe childhood atopic dermatitis. Over half of pediatric patients showed improvement, with significant score reductions and good tolerability, making it a viable option for refractory cases.

Area of Science:

  • Dermatology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Atopic dermatitis is a chronic inflammatory skin condition.
  • Methotrexate is an off-label systemic treatment for severe atopic dermatitis.
  • Pediatric patients with uncontrolled atopic dermatitis often require systemic therapy.

Purpose of the Study:

  • To evaluate the safety and efficacy of methotrexate in children with atopic dermatitis.
  • To assess treatment outcomes in pediatric patients with refractory atopic dermatitis.

Main Methods:

  • Multicenter, retrospective study design.
  • Review of medical records for 26 pediatric patients.
  • Analysis of Investigator Global Assessment (IGA) scores before and after methotrexate treatment.

Main Results:

  • 53.85% of patients experienced clinical improvement at 3 and 6 months.
  • Significant reduction in IGA scores observed at 3 and 6 months post-treatment.
  • High tolerability with only one patient discontinuing treatment due to adverse events (10.35%).
  • Median patient satisfaction rate of 7.5/10.

Conclusions:

  • Methotrexate is a tolerable and effective treatment for refractory childhood atopic dermatitis.
  • The study supports the use of methotrexate in pediatric patients with severe atopic dermatitis.
  • Further research may explore long-term outcomes and optimal dosing.
Abstract

Keywords:
Atopic dermatitisatopic eczemachildhoodmethotrexate

More Related Videos

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

18.0K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.0K

Related Concept Videos

Erikson's Theory on Socioemotional Development during Childhood01:28

Erikson's Theory on Socioemotional Development during Childhood

Erik Erikson, a stage theorist, adapted Freud's theory to emphasize social factors in personality development throughout life, a concept known as psychosocial development. Unlike Freud, who focused on early childhood, Erikson believed that personality evolves across eight life stages, each marked by a specific challenge or "crisis." Successful resolution of each stage fosters competence, while failure may lead to feelings of inadequacy.
The first four of Erikson's eight...
1.1K
Piaget's Theory of Cognitive Development from Childhood into Adulthood01:25

Piaget's Theory of Cognitive Development from Childhood into Adulthood

Jean Piaget's theory of cognitive development emphasizes the role of thinking in a child's learning process, suggesting that children are naturally curious about their environment. His approach to development is discontinuous, proposing that cognitive abilities progress through distinct stages, each with unique characteristics. Central to Piaget's theory is schemata—mental structures that allow individuals to understand and interpret the world.
Schemata: Building Blocks of Knowledge
1.6K
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.3K
Case Studies01:22

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
13.6K
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
370
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
533