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Updated: Feb 6, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Efficient and regioselective synthesis of γ-lactone glycosides through a novel debenzylative cyclization reaction
Julien A Delbrouck1, Abdellatif Tikad, Stéphane P Vincent
1University of Namur, Département de Chimie, Laboratoire de Chimie Bio-Organique, Rue de Bruxelles 61, B-5000 Namur, Belgium. stephane.vincent@unamur.be.
Abstract:
An efficient and regioselective approach for the construction of synthetically important γ-lactone glycosides is reported from unprotected aldoses through a new debenzylative lactonization (DBL) reaction. The scope and limitations of this DBL reaction are described starting from a series of commercially available hexoses (l-fucose, d-galactose, d-glucose) and pentoses (d-arabinose, d-ribose, d-lyxose, d-xylose) to afford the corresponding γ-lactones in good yields and without concomitant δ-lactone formation.
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