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Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases

Christina Schoenherr1, Margaret C Frame1, Adam Byron1

  • 1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom;

Annual Review of Cell and Developmental Biology
|August 16, 2018
PubMed

Insights

Cell adhesion is vital for tissue health, but errors can cause disease. This review explores how protein trafficking regulates cell adhesion signaling and function.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Cell adhesion is crucial for tissue development and homeostasis.
  • Dysregulated cell adhesion is implicated in diseases like cancer and fibrosis.
  • Signaling pathways involving kinases and scaffolding proteins mediate cell adhesion.

Purpose of the Study:

  • To review the spatial regulation of cell adhesion and growth factor receptors.
  • To explore the trafficking mechanisms of key signaling proteins.
  • To highlight novel biological functions revealed by protein trafficking.

Main Methods:

  • Literature review of cell adhesion research.
  • Analysis of protein trafficking pathways.
  • Integration of biomechanical and biochemical signaling mechanisms.

Main Results:

  • Cell adhesion receptor and signaling protein trafficking is complex and diverse.
  • Unexpected subcellular trafficking reveals novel biological functions.
  • Spatial regulation is key to integrating adhesion with other cellular processes.

Conclusions:

  • Understanding protein trafficking is essential for comprehending cell adhesion.
  • Novel therapeutic targets may emerge from studying spatial regulation of signaling.
  • Further research into receptor trafficking will illuminate disease mechanisms.
Keywords:
adhesion receptorsendosomesgrowth factor receptorskinasesnucleusprotein trafficking

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