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Current Screening Methodologies in Drug Discovery for Selected Human Diseases.

Olga Maria Lage1,2, María C Ramos3, Rita Calisto4,5

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Marine Drugs
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Drug discovery faces challenges from multidrug-resistant infections. Advances in understanding disease, genomics, models, and technology will drive future drug development for various diseases.

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Area of Science:

  • Pharmacology and Drug Discovery
  • Microbiology
  • Genomics

Background:

  • Rising prevalence of deadly diseases, particularly multidrug-resistant bacterial infections, necessitates innovative drug discovery approaches.
  • Understanding disease metabolism, microbial genomics, and improved biological models are crucial for future pharmaceutical advancements.

Purpose of the Study:

  • To review current methodologies in drug discovery for various therapeutic areas.
  • To explore complementary approaches: phenotypic and target-based drug discovery.
  • To highlight future trends and recent advances in the pharmaceutical industry.

Main Methods:

  • Consideration of classical (phenotypic) and reverse (target-based) pharmacology.
  • Screening methods for natural product discovery, including terrestrial and marine sources.
  • Analysis of advancements in biological techniques, technologies, and computation.

Main Results:

  • Phenotypic drug discovery has been instrumental in identifying natural products.
  • Marine natural products represent a promising source for novel therapeutics.
  • Integration of genomics, advanced models, and computational tools will accelerate discovery.

Conclusions:

  • Drug discovery requires a multifaceted approach, combining classical and novel strategies.
  • Continued research into disease mechanisms and microbial genomes is essential.
  • Future drug discovery will be significantly enhanced by technological and computational progress.