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Relationship between ABCA1 gene polymorphism and lacunar infarction combined with arteriosclerosis in patients

Yao Xu1, Zhenqiang Li2,3

  • 1Department of Neurology, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China.

Experimental and Therapeutic Medicine
|August 17, 2018
PubMed

Insights

The Adenosine triphosphate-binding cassette transporter A1 (ABCA1) R219K gene polymorphism is not associated with lacunar infarction (LI) complicated by arteriosclerosis. This study found no genetic link between ABCA1 R219K and LI with arteriosclerosis.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Biochemistry

Background:

  • Lacunar infarction (LI) combined with arteriosclerosis is a significant health concern.
  • The role of Adenosine triphosphate-binding cassette transporter A1 (ABCA1) gene polymorphism in LI with arteriosclerosis requires further investigation.
  • Understanding genetic predispositions can aid in developing targeted prevention strategies.

Purpose of the Study:

  • To investigate the association between Adenosine triphosphate-binding cassette transporter A1 (ABCA1) gene R219K polymorphism and lacunar infarction (LI) complicated with arteriosclerosis.
  • To analyze serum lipid profiles and apolipoprotein levels in patients with LI and arteriosclerosis compared to healthy controls.
  • To determine the correlation between ABCA1 R219K genotypes and susceptibility to LI with arteriosclerosis.

Main Methods:

  • Case-control study involving 112 LI patients with arteriosclerosis and 342 healthy controls.
  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) used to detect ABCA1 R219K gene polymorphism.
  • Serum levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-I (ApoA-I), apolipoprotein B (ApoB), and lipoprotein (a) [Lp(a)] were measured.

Main Results:

  • Patients with LI and arteriosclerosis exhibited significantly higher TG and ApoB levels, and lower ApoA-I and HDL-C levels compared to controls.
  • No significant differences were observed in the frequencies of RR, RK, and KK genotypes or allele frequencies of ABCA1 R219K between the two groups.
  • Serum lipid and apolipoprotein levels did not show significant differences among different ABCA1 R219K genotypes.

Conclusions:

  • The Adenosine triphosphate-binding cassette transporter A1 (ABCA1) R219K polymorphism is not correlated with the susceptibility to lacunar infarction complicated with arteriosclerosis.
  • While lipid profiles differ between patients and controls, the ABCA1 R219K genotype does not appear to be a contributing genetic factor.
  • Further research may explore other genetic variants or environmental factors influencing LI combined with arteriosclerosis.

Keywords:
ABCA1 geneR219Karteriosclerosislacunar infarction

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