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Related Concept Videos

Diffusion01:12

Diffusion

219.9K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
219.9K
Diffusion01:21

Diffusion

6.4K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.4K
Facilitated Diffusion01:16

Facilitated Diffusion

1.3K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.3K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

31.4K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
31.4K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

5.7K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
5.7K
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

1.7K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.7K

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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

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Diffuse large B-cell lymphoma: An institutional analysis.

Ajay Gogia1, Chandan K Das1, Lalit Kumar1

  • 1Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

South Asian Journal of Cancer
|August 17, 2018
PubMed
Summary
This summary is machine-generated.

This study found that adding rituximab to chemotherapy improved response rates and event-free survival for diffuse large B-cell lymphoma (DLBCL) patients. Rituximab-based regimens offer better outcomes regardless of the lymphoma

Keywords:
Diffuse large B-cell lymphomaIndiaoutcomerituximab

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Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is the most prevalent form of non-Hodgkin's lymphoma.
  • Understanding DLBCL patient characteristics and treatment outcomes is crucial for improving patient care.

Purpose of the Study:

  • To analyze clinicopathological features of DLBCL patients.
  • To evaluate the impact of rituximab on treatment response and survival in DLBCL.
  • To investigate the role of cell of origin in DLBCL treatment outcomes.

Main Methods:

  • Retrospective analysis of 267 DLBCL patients treated between May 2013 and July 2015.
  • Data collected included demographics, clinical presentation, histopathology, stage, International Prognostic Index (IPI), and treatment details.
  • Cell of origin and treatment outcomes, including response rates and event-free survival (EFS), were assessed.

Main Results:

  • The study included 267 patients with a median age of 49 years; 52% had early-stage disease.
  • Germinal center B-cell (GCB) origin was observed in 55% and activated B-cell (ABC) in 45% of cases with available data.
  • Overall response rate was 84%, with complete response (CR) of 70.5%. Rituximab plus CHOP (RCHOP) showed significantly higher CR rates (77%) than CHOP alone (61.5%). Two-year EFS was 70%, with RCHOP associated with better EFS.

Conclusions:

  • Adding rituximab to CHOP chemotherapy significantly improved response rates and EFS in DLBCL patients.
  • The benefit of rituximab was observed irrespective of the lymphoma's cell of origin.
  • This study provides evidence for the efficacy of rituximab-based therapy in DLBCL from India.