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Updated: Feb 6, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Cobalt-Catalyzed Enantioselective Synthesis of Chiral gem-Bis(boryl)alkanes
1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
Abstract:
We report an asymmetric synthesis of enantioenriched gem-bis(boryl)alkanes in an enantioselective diborylation of 1,1-disubstituted alkenes catalyzed by Co(acac)2 /(R)-DM-segphos. A range of activated and unactivated alkenes underwent this asymmetric diborylation in the presence of cyclooctene as a hydrogen acceptor, affording the corresponding gem-bis(boryl)alkanes with high enantioselectivity. The synthetic utility of these chiral organoboronate compounds was demonstrated through several stereospecific derivatizations and the synthesis of sesquiterpene and sesquiterpenoid natural products.
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