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Aortic dissection detection risk score has high sensitivity with moderate inter-rater reliability.

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The aortic dissection detection risk score (ADD-RS) showed 100% sensitivity for diagnosing acute aortic dissection in this study. Further prospective evaluation is recommended.

Keywords:
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Area of Science:

  • Emergency Medicine
  • Cardiovascular Diagnostics
  • Diagnostic Accuracy Studies

Background:

  • Acute aortic dissection is a life-threatening condition requiring rapid diagnosis.
  • The aortic dissection detection risk score (ADD-RS) is a clinical tool developed to aid in diagnosis.
  • Evaluating the performance of diagnostic scores in real-world settings is crucial.

Purpose of the Study:

  • To retrospectively assess the diagnostic accuracy of the aortic dissection detection risk score (ADD-RS).
  • To evaluate the inter-rater reliability of the ADD-RS among clinicians.
  • To determine the sensitivity and predictive values of the ADD-RS in a tertiary hospital emergency department.

Main Methods:

  • Retrospective, single-centre, observational study.
  • Inclusion of 200 patients presenting to the emergency department.
  • Analysis of ADD-RS scores and correlation with confirmed acute aortic dissection diagnoses.

Main Results:

  • Five patients were diagnosed with acute aortic dissection, all with an elevated ADD-RS (>0).
  • The ADD-RS demonstrated 100% sensitivity for detecting acute aortic dissection.
  • Negative and positive predictive values were 100% when ADD-RS was ≥1, with moderate inter-rater reliability (Kappa = 0.55).

Conclusions:

  • The ADD-RS exhibited high sensitivity in the studied patient cohort.
  • The findings support the ADD-RS as a sensitive tool for ruling out acute aortic dissection.
  • Prospective validation and investigation of the ADD-RS in combination with D-dimer testing are warranted.