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Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
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Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery

Jianming Liang1,2,3, Caifang Gao2,3, Ying Zhu1

  • 1Guangzhou University of Chinese Medicine , Guangzhou 510006 , PR China.

ACS Applied Materials & Interfaces
|August 17, 2018
PubMed

Insights

A new drug delivery system using albumin nanoparticles modified with traditional Chinese medicine components effectively targets glioma. This approach enhances drug delivery across the blood-brain barrier (BBB) for improved brain cancer therapy.

Area of Science:

  • Nanomedicine
  • Neuro-oncology
  • Pharmacology

Background:

  • Glioma treatment is hindered by poor drug penetration across the blood-brain barrier (BBB).
  • Current drug delivery methods face limitations in efficiency and side effects.
  • Traditional Chinese medicine components offer potential for enhancing brain drug delivery.

Purpose of the Study:

  • To develop a novel glioma-targeting drug delivery system using enhancer-modified albumin nanoparticles.
  • To evaluate the safety and efficiency of this system in crossing the BBB and targeting glioma.
  • To explore a new strategy for overcoming BBB limitations in brain drug delivery.

Main Methods:

  • Screening of brain penetration enhancers from traditional Chinese medicine.
  • Development of albumin nanoparticles modified with selected enhancers.
  • In vitro assessment of nanoparticle transport across brain capillary endothelial cell (BCEC) monolayers.
  • In vivo imaging to evaluate brain penetration and glioma targeting.
  • Assessment of biocompatibility and cytotoxicity.

Main Results:

  • The enhancer-modified albumin nanoparticles significantly improved transport across the BCEC monolayer by enhancing endocytosis and causing mild BBB disruption.
  • In vivo studies showed superior brain entry and glioma accumulation compared to transferrin-modified nanoparticles.
  • Nanoparticles demonstrated potential for bypassing the BBB via fenestrae in the pineal gland.
  • The developed nanosystem exhibited good biocompatibility and low cytotoxicity.

Conclusions:

  • Enhancer-modified albumin nanoparticles represent an efficient and safe strategy for glioma drug delivery.
  • This approach shows promise for improving therapeutic outcomes in brain cancer.
  • Utilizing traditional Chinese medicine components offers a novel avenue for overcoming BBB challenges.
Keywords:
BBB-disruptingbrain penetration enhancerbrain permeabilitygliomamentholpineal gland

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