Normative Data on Foveal Avascular Zone Dimensions in Four Macular Vascular Layers

To provide normative data on the size of the foveal avascular zone (FAZ) in the four histological retinal vascular layers as measured using optical coherence tomography angiography (OCTA) and evaluate interobserver variability.

Two graders measured the FAZ area in each layer (nerve fiber layer [NFL], ganglion cell layer [GCL], inner plexiform layer to inner nuclear layer [INL], and INL to outer plexiform layer), as well as the superficial and deep capillary plexuses.

Forty-seven eyes of 25 subjects were included. The FAZ was not clearly delineated in the NFL or GCL layers. There was high agreement between measurements of the FAZ area of the different layers. Inter- and intraobserver agreements were high.

This is the first study to measure FAZ size across the retina. There was a high correlation between FAZ sizes among the different layers on OCTA. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:580-586.].