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Updated: Feb 6, 2026

Isolation, Culture, and Transplantation of Muscle Satellite Cells
Published on: April 8, 2014
Runx1 promotes satellite cell proliferation during ischemia - Induced muscle regeneration
Meiyu Bao1, Songbai Liu2, Xi-Yong Yu3
1Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Abstract:
RUNX1 is a transcription factor that is not expressed in uninjured muscles, but can be detected in denervated muscles, suggesting a role of RUNX1 in muscle's response to injury. However, the role of RUNX1 in muscle's response to ischemia has not been reported. Our study showed that Runx1 is up regulated in skeletal muscle during ischemia reperfusion induced injury. Over-expression of Runx1 in C2C12 cells inhibits myogenic differentiation, but promotes proliferation of myoblasts. Consistent with these findings, we found that Runx1 expression was decreased in differentiated satellite cells. Our results indicate that Runx1 regulates muscle regeneration by promoting proliferation of satellite cells.
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