Utility of standardized discharge criteria after appendectomy to identify pediatric patients requiring intervention

Kathryn Tinsley Anderson1, Marisa A Bartz-Kurycki1, KuoJen Tsao1

  • 1Center for Surgical Trials and Evidence-based Practice, Department of Pediatric Surgery at McGovern Medical School at The University of Texas Health Science Center at Houston and Children's Memorial Hermann Hospital, Houston, TX.

Surgery
|August 18, 2018
PubMed

Insights

Standardized criteria for identifying pediatric appendectomy discharge failure can reduce unnecessary postoperative imaging. A selective imaging approach in pediatric appendicitis management effectively identifies complications requiring intervention.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Radiology

Background:

  • Appendectomy is a common pediatric surgical procedure.
  • Identifying appropriate candidates for postoperative imaging is crucial for efficient management.
  • Failure-of-discharge criteria can help stratify risk in pediatric appendicitis cases.

Purpose of the Study:

  • To evaluate the effectiveness of failure-of-discharge criteria in pediatric appendectomy patients.
  • To identify which pediatric patients post-appendectomy would benefit from postoperative imaging.
  • To determine if postoperative imaging impacts management decisions.

Main Methods:

  • Retrospective review of 3,276 pediatric appendectomy patients (July 2009-May 2017).
  • Defined complicated appendicitis based on intraoperative findings.
  • Utilized specific failure-of-discharge criteria (fever, leukocytosis, diet intolerance, pain) for recommending imaging (postoperative days 5-7).

Main Results:

  • 12% of patients met at least one failure-of-discharge criterion.
  • 79% of these patients underwent postoperative imaging (CT, US, or combined).
  • 39% of imaged patients required intervention; diet intolerance, fever, leukocytosis, complicated disease, and age were associated with intervention need.

Conclusions:

  • Standardized discharge failure criteria can minimize unnecessary postoperative imaging after pediatric appendectomy.
  • A selective imaging strategy in pediatric appendicitis management yields a high rate of interventions when complications are suspected.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
266
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
314
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
237
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
305
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.3K
Criteria for Causality: Bradford Hill Criteria - I01:30

Criteria for Causality: Bradford Hill Criteria - I

The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
1.1K