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Superoxide production of polymorphonuclear leukocytes in surgical patients with gastric cancer
Abstract:
Superoxide production (SOP) by polymorphonuclear leukocytes (PMNs) in 65 gastric cancer patients, who were in preoperative state and had received no medical therapy, was assayed in order to evaluate the bactericidal activity of PMNs in cancer patients, as well as to determine the correlation of SOP by PMNs with postoperative prognoses and several factors by which extent of disease and the clinical or histological character of gastric carcinoma were defined. Patients with stage II disease had a tendency to have an increased SOP by PMNs, and furthermore, as the disease progressed, the SOP by PMNs decreased with significant depression being noted in stage III and IV cases compared to healthy controls. Significantly reduced SOP by PMNs was observed in n2 and n3 cases and with se, si, sei and/or ps(+) pathological invasion. SOP by PMNs in patients with Borrmann II type and/or poorly differentiated adenocarcinoma was significantly depressed. Patients who suffered from septic complications showed a significant depression in SOP by PMNs compared with the controls and no complication group. These results suggest that advanced gastric cancer patients may have defective oxidative PMN metabolism, and that a decrease of SOP is a contributory cause of high susceptibility to postoperative infection in cancer patients.
Insights
Gastric cancer patients show decreased superoxide production (SOP) by polymorphonuclear leukocytes (PMNs), impacting their ability to fight bacteria. This reduced SOP correlates with advanced disease stages and increased infection risk, suggesting impaired immune function.
Area of Science:
- Immunology
- Oncology
- Gastroenterology
Background:
- Polymorphonuclear leukocytes (PMNs) are crucial for innate immunity, with superoxide production (SOP) being a key bactericidal mechanism.
- Gastric cancer can potentially impair immune cell function, affecting patient outcomes and infection susceptibility.
Purpose of the Study:
- To evaluate the bactericidal activity of PMNs in gastric cancer patients by measuring SOP.
- To determine the correlation between PMN SOP and disease stage, clinicopathological features, and postoperative prognosis in gastric cancer.
Main Methods:
- Assay of superoxide production (SOP) in polymorphonuclear leukocytes (PMNs) from 65 preoperative gastric cancer patients.
- Comparison of SOP levels between different disease stages, pathological invasion statuses, tumor types, differentiation grades, and complication groups.
Main Results:
- A tendency for increased SOP in stage II gastric cancer, followed by a significant decrease in stages III and IV compared to controls.
- Significantly reduced SOP in patients with advanced nodal (n2, n3) and vascular/perineural invasion (se, si, sei, ps+).
- Depressed SOP observed in Borrmann II type tumors, poorly differentiated adenocarcinomas, and patients with septic complications.
Conclusions:
- Advanced gastric cancer is associated with defective oxidative metabolism in PMNs.
- Decreased SOP in PMNs contributes to increased susceptibility to postoperative infections in gastric cancer patients.