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Related Concept Videos

Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Color in Coordination Complexes
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Improving Stem Cell Delivery to the Trabecular Meshwork Using Magnetic Nanoparticles.

E J Snider1, K P Kubelick1, K Tweed1

  • 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia.

Scientific Reports
|August 18, 2018
PubMed
Summary
This summary is machine-generated.

Magnetic nanoparticles enable targeted delivery of stem cells to the trabecular meshwork (TM) for glaucoma treatment. This method enhances stem cell delivery efficiency for potential ocular hypertension therapies.

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Glaucoma is a leading cause of blindness, often linked to elevated intraocular pressure.
  • Reduced cellularity in the trabecular meshwork (TM) is a hallmark of glaucoma.
  • Stem cell therapy presents a potential strategy for controlling intraocular pressure in glaucoma.

Purpose of the Study:

  • To develop a method for targeted delivery of stem cells to the TM.
  • To investigate the use of magnetic nanoparticles for guiding stem cells within the eye.
  • To assess the efficacy and safety of magnetically guided stem cell delivery for glaucoma treatment.

Main Methods:

  • Mesenchymal stem cells were labeled with Prussian blue nanocubes (PBNCs).
  • PBNC-labeled stem cells were injected into the anterior chamber of the eye.
  • A magnetic field was applied to steer the labeled stem cells towards the TM.
  • Cell viability and multipotency were assessed post-labeling.

Main Results:

  • PBNC-labeled stem cells demonstrated significantly increased delivery to the TM compared to unlabeled cells.
  • Magnetic steering enabled delivery of stem cells to the entire TM circumference.
  • PBNC labeling did not compromise stem cell viability or multipotency.
  • Targeted delivery was achieved within clinically relevant timeframes (15 minutes).

Conclusions:

  • Prussian blue nanocube labeling facilitates targeted and efficient delivery of stem cells to the TM.
  • This technique offers a promising approach for regenerative medicine strategies in glaucoma.
  • Magnetic guidance of stem cells represents a viable method for controlling ocular hypertension.