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Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

Peter Nambala1, Wen-Chi Su1,2

  • 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.

Frontiers in Microbiology
|August 18, 2018
PubMed

Insights

Understanding Zika virus precursor membrane (prM) protein is crucial for developing effective vaccines. This review highlights prM

Area of Science:

  • Virology and Immunology
  • Infectious Diseases

Background:

  • Recent Zika virus (ZIKV) epidemics highlight the need for rapid development of medical countermeasures.
  • ZIKV precursor membrane (prM) protein is essential for viral particle maturation via cleavage into M protein.
  • Emerging evidence suggests a potential role for prM in ZIKV-associated neurovirulence.

Purpose of the Study:

  • To review current knowledge regarding the ZIKV prM protein.
  • To explore the application of prM in the development of ZIKV vaccines.

Main Methods:

  • Comprehensive literature review of studies on ZIKV prM protein.
  • Analysis of ZIKV vaccine strategies incorporating prM as an immunogen.

Main Results:

  • prM protein is a key structural component involved in ZIKV assembly.
  • prM's potential involvement in ZIKV neurovirulence is an active area of research.
  • prM is a common component in current ZIKV vaccine candidates.

Conclusions:

  • Enhanced understanding of ZIKV prM biology is vital for accelerating vaccine development.
  • prM remains a significant target for ZIKV vaccine design and evaluation.
Keywords:
ZIKVepidemicprMvaccineviral pathogenicity

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