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Related Experiment Video

Updated: Feb 6, 2026

Experimental Approaches to Tissue Engineering

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Molecular Approaches to Safe and Controlled Engineered T-cell Therapy.

R S Kalinin¹, A V Petukhov¹, V D Knorre¹

¹M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str. 16 /10, Moscow, 117997, Russia.

|August 18, 2018

Summary

This summary is machine-generated.

Chimeric antigen receptor (CAR)-T therapy enhances cancer treatment but requires safer designs. This study reviews molecular engineering strategies to improve CAR T-cell therapy safety and control for better clinical outcomes.

Keywords:

T-cells cancer cells cell therapy chimeric antigen receptors

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Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Area of Science:

Immunology
Oncology
Biotechnology

Background:

Chimeric antigen receptor (CAR)-T therapy is a rapidly advancing immuno-oncology treatment.
CAR-T therapy has transformed cell therapy, accelerating development from preclinical models to clinical use.
Early CAR T-cell applications highlighted the need for enhanced safety and controlled T-cell activation.

Purpose of the Study:

To review molecular engineering approaches for CARs.
To identify strategies for mitigating clinical risks associated with CAR-T therapy.

Main Methods:

Literature review of CAR engineering strategies.
Analysis of molecular modifications in CAR T-cell therapy.

Main Results:

Initial CAR designs prioritized T-cell activation, cytotoxicity, and persistence.
Subsequent research focused on safety and controlled activation mechanisms.
Various molecular engineering techniques have been developed to address safety concerns.

Conclusions:

Molecular engineering of CARs is crucial for enhancing the safety of T-cell therapy.
Controlled activation of CAR T-cells is essential for reducing clinical risks.
Continued innovation in CAR design is vital for the successful clinical application of T-cell therapy.