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Related Experiment Video

Updated: Feb 6, 2026

Use of Dual Optical Tweezers and Microfluidics for Single-Molecule Studies

Use of Dual Optical Tweezers and Microfluidics for Single-Molecule Studies

Published on: November 18, 2022

Optical tweezers for trapping in a microfluidic environment.

R Kampmann, S Sinzinger, J G Korvink

|August 18, 2018

Summary

This study presents optical tweezers designed for micro-NMR spectroscopy, enabling precise positioning of small objects without disturbing magnetic fields. The developed system successfully trapped fused silica particles, demonstrating its effectiveness for sensitive measurements.

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Last Updated: Feb 6, 2026

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Published on: January 15, 2013

Area of Science:

Physics
Spectroscopy
Microfluidics

Background:

Optical tweezers offer non-contact manipulation using light forces.
Integration with microfluidics and NMR spectroscopy requires precise, non-magnetic positioning tools.

Purpose of the Study:

To design and construct optical tweezers for micro-NMR spectroscopy.
To achieve precise object positioning within a microfluidic channel for NMR detection.
To avoid susceptibility-disturbing materials in the measurement setup.

Main Methods:

Utilized geometrical optics and ray fan description for optical force simulation.
Employed an iterative design process to meet system constraints.
Characterized components using vertical scanning interferometry and assembled a monolithic optical component.

Main Results:

Designed and manufactured an efficient optical trapping system tailored to application requirements.
Successfully demonstrated optical trapping of fused silica particles.
Developed a system compatible with wide-bore superconducting magnets for micro-NMR applications.

Conclusions:

The developed optical tweezers are suitable for precise positioning in micro-NMR spectroscopy.
The system design successfully addressed the constraints of non-magnetic interference and precise manipulation.
This technology enables advanced spectroscopic analysis of small objects within microfluidic devices.