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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
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Mapping molecular HLA typing data to UNOS antigen equivalents
Navchetan Kaur1, Evan P Kransdorf2, Marcelo J Pando3
1Department of Pathology and Laboratory Medicine, Tulane Cancer Center, Tulane University School of Medicine, New Orleans, USA.
Human Immunology
|August 18, 2018
Summary
Histocompatibility labs can now easily convert molecular HLA typing data to UNOS antigen equivalencies using a new table and web application. This tool simplifies data entry into the UNet system, improving transplant efficiency.
Area of Science:
- Immunogenetics
- Transplantation Science
Background:
- Histocompatibility laboratories require conversion of molecular HLA typing data to antigen equivalencies for the UNOS UNet system.
- Existing guidelines are general, and the lack of a comprehensive antigen mapping table complicates this conversion process.
Purpose of the Study:
- To present a UNOS antigen equivalency table for all IPD-IMGT/HLA alleles at key loci (A, B, C, DRB1, DRB3/4/5, DQA1, DQB1).
- To develop tools for automated conversion of HLA typing data to UNOS antigen equivalents.
Main Methods:
- An automated script was developed using data from WMDA, HLA Dictionary, and UNOS.
- Validation involved converting NMDP allele frequencies to antigen equivalents and comparing with UNOS CPRA panels.
- An open-source web application (ALLAN) and web services were created.
Main Results:
- High frequency similarity scores (0.85-0.97) between NMDP and UNOS panels across diverse US populations confirmed accurate antigen mapping.
- The ALLAN web application and services enable mapping of HLA typing data to UNOS antigen equivalents using population-specific frequencies.
Conclusions:
- Computer-assisted interpretation of molecular HLA data can reduce UNet typing discrepancies.
- This work facilitates direct utilization of molecular typing data in UNet match runs and virtual crossmatches.
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