Related Experiment Video
Updated: Feb 6, 2026
05:56
Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
2.1K
Ictal nausea and vomiting - Is it left or right?
Alexander A Tarnutzer1, Ian Mothersill2, Lukas L Imbach1
1Department of Neurology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland.
Seizure
|August 18, 2018
Summary
Ictal nausea and vomiting are common seizure symptoms but do not reliably indicate the seizure
Area of Science:
- Neurology
- Epileptology
- Clinical Neurophysiology
Background:
- Ictal nausea/vomiting are considered potential lateralizing signs in epilepsy.
- Previous studies suggest a link to the non-dominant hemisphere.
- However, conflicting reports exist regarding seizure localization.
Purpose of the Study:
- To investigate the seizure localization and lateralization in patients experiencing ictal nausea/retching/vomiting.
- To test the hypothesis that these symptoms possess lateralizing value.
Main Methods:
- Retrospective analysis of video-electroencephalography (video-EEG) data from two large epilepsy centers (1980-2017).
- Inclusion of patients with focal epilepsy and documented ictal nausea/retching/vomiting.
- Extraction of seizure location, lateralization, and clinical symptoms from EEG reports.
Main Results:
- 13 patients with focal epilepsy and ictal nausea/retching/vomiting were identified.
- Seizures predominantly originated from the temporal lobe (12/13 patients).
- The distribution of seizures to the dominant versus non-dominant hemisphere was not statistically significant, suggesting no lateralizing value.
Conclusions:
- Ictal nausea/retching/vomiting are most commonly associated with temporal lobe epilepsy.
- Contrary to prior beliefs, these symptoms do not appear to have significant lateralizing value.
- Video-EEG is essential for accurate seizure localization and lateralization, as clinical signs alone are insufficient.
Related Concept Videos
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
790
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
790
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
681
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
681
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
890
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
890
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
627
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
627
01:22Pathophysiology of Vomiting
3.1K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
3.1K
01:24Cardiac Catheterization III: Left Heart Catheterization
742
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
742