Related Experiment Video
Updated: Feb 6, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
CFA Models with a General Factor and Multiple Sets of Secondary Factors
Minjeong Jeon1, Frank Rijmen2, Sophia Rabe-Hesketh3
1Department of Education, University of California, Los Angeles, 457 Portola Plaza, Los Angeles, CA, 90095, USA. mjjeon@ucla.edu.
Abstract:
We propose a class of confirmatory factor analysis models that include multiple sets of secondary or specific factors and a general factor. The general factor accounts for the common variance among manifest variables, whereas multiple sets of secondary factors account for the remaining source-specific dependency among subsets of manifest variables. A special case of the model is further proposed which constrains the specific factor loadings to be proportional to the general factor loadings. This proportional model substantially reduces the number of model parameters while preserving the essential structure of the general model. Furthermore, the proportional model allows for the interpretation of latent variables as the expected values of the observed manifest variables, decomposition of the variances, and the inclusion of interactions, similar to generalizability theory. We provide two applications to illustrate the utility of the proposed class of models.
Related Concept Videos
Transcription Factors
Factors Affecting Solubility
Transcription Elongation Factors
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
Factors Affecting Drug Distribution: Miscellaneous Factors
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Electrolytes: van't Hoff Factor
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
Factors Affecting Protein-Drug Binding: Drug-Related Factors
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...

