Related Experiment Video For epigenetic(s)
Updated: Feb 6, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Epithelial-mesenchymal transition and microRNAs: Challenges and future perspectives in oral cancer
Cátia Sofia da Costa Domingues1,2,3,4, Beatriz Prazeres Serambeque3,5, Mafalda Sofia Laranjo Cândido3,5,6
1Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Background:
Head and neck cancer is the sixth most common cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most representative type. OSCC is a public health problem with high morbidity and poor survival rate. Epithelial-mesenchymal transition is emerging as a hallmark in OSCC.
Methods:
In this study, we described the role of microRNAs in epithelial-mesenchymal transition regulation in OSCC based on a PubMed search using articles published in English between January 1, 2010, and January 31, 2018.
Results:
MicroRNA's regulatory networks seem to be a hallmark of epithelial-mesenchymal transition in OSCC pathophysiology becoming a growing challenge to design new studies and strategies from biology to clinical applications.
Conclusion:
Therefore, we propose that targeting therapies to epithelial-mesenchymal transition-type cells, namely, coordinating microRNAs and/or hydrophobic drugs, such as conventional therapy, could be a promising strategy to improve the outcomes of patients with OSCC.
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